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butabarbital will minimize the level or result of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Outcome of coadministering a strong CYP3A4 inducer with fedratinib hasn't been studied.butabarbital will reduce the level or influence of carvedilol by influencing hepatic enzyme CYP2C9/10 met